Corticosteroids and multiple sclerosis.

It is common practice to employ a short course of corticosteroids to treat acute relapses of multiple sclerosis. Two approaches, high dose intravenous methylpred-nisolone (IVMP) and intramuscular ACTH, have been shown when compared to placebo to shorten the duration of relapses, 1 2 although there is no evidence that the final outcome is changed. Of these, IVMP has become the more popular, being a shorter course (typically 3–5 days versus 2 weeks), and indeed ACTH is no longer available for use in the United Kingdom. Relatively small studies have suggested equivalence between oral corticosteroids (using various dose regimes) and IVMP in treating multiple sclerosis relapses, 3 although the first has not been tested against placebo. In a placebo controlled trial in acute optic neuritis, oral prednisone was not associated with an increased rate of visual recovery, whereas IVMP followed by an oral tapering oV period was. 4 With this incomplete data from controlled trials, it is not surprising that a survey of United Kingdom neurologists (see Tremlett et al, this volume, pp 362–5) has disclosed widely variable patterns of corticosteroid prescribing in patients with multiple sclerosis. There was consensus that a short course of steroids is indicated to treat a proportion of multiple sclerosis relapses, and it was clear that IVMP for 3–5 days is widely adopted as the most popular regime. Beyond these facts, no clear pattern emerged. Although most neurologists will occasionally prescribe oral corticos-teroids, there was no consensus as to agent (prednisolone, methylprednisolone, and dexamethasone were all used), dose, or duration of treatment. Nor was there any consensus on the need for an oral tapering oV period after a course of IVMP or the duration of such a taper if used. Given the lack of evidence for eYcacy, and the potential for side eVects, it is of concern that corticosteroids were occasionally given in courses exceeding one month and to treat progressive forms of the disease. The authors suggest that a further large trial would be needed to clarify outstanding issues—for example, the relative merits of IVMP versus oral prednisolone. This may be true, and as the authors say, an unambiguous demonstration of equivalence will have health economic benefits, given the significant cost of a course of IVMP. On the other hand, a large and expensive trial might demonstrate superiority of IVMP, and result in no change in current practice. It is perhaps more important to consider …